Table 1.
Summary and Characteristics of Studies Identified in Systematic Review.
| Study No. | First Author, Year of Publication | n (Patients) | Male | Female | Age in Years, Mean (Range) | Lesion Size in cm2, Mean (Range) | Lesion Location: Condylar (Fc), Patellar (P), Tibial Plateau (Tp), Trochlear (T) | Follow-up in Years, Mean (Range) | Level of Evidence | Level of Evidence, Study Methodology | ACI | OATS | OCA | MFX | IKDC | Lysholm | VAS Pain | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Cvetanovich, 2017 | 37 | 15 | 22 | 16.7 (13-18) | 4 | Fc, P, T | 4.6 (2-10.6) | Level IV | Case series | ✓ | ✓ | ✓ | |||||
| 2 | Gudas, 2009 | 25 | 15 | 10 | 14.6 (12-18) | 3.2 | Fc | 4.2 (3-6) | Level I | Randomized controlled trial | ✓ | ✓ | ||||||
| 2 | Gudas, 2009 | 22 | 13 | 9 | 14.1 (12-18) | 3.2 | Fc | 4.2 (3-6) | Level I | Randomized controlled trial | ✓ | ✓ | ||||||
| 3 | Lee, 2012 | 5 | 1 | 4 | 14.6 (12-17) | 1.2 (1-1.5) | P | 2.5 (1.3-4.5) | Level IV | Case series | ✓ | ✓ | ✓ | |||||
| 4 | Macmull, 2011 | 31 | 22 | 9 | 16.3 (14-18) | 5.3 (1.0-15.8) | Fc, P, T | 5.5 (1-10.5) | Level IV | Case series | ✓ | ✓ | ✓ | |||||
| 5 | Micheli, 2006 | 37 | 22 | 15 | 15.5 (11-17) | 5.2 (1.9-14) | Fc | 4.3 | Level IV | Case series | ✓ | ✓ | ||||||
| 6 | Mithöfer, 2005 | 20 | 15 | 5 | 15.9 (12-18) | 6.4 (2.4-14) | Fc, P, Tp, T | 3.9 (1.9-7.6) | Level IV | Case series | ✓ | ✓ | ✓ | |||||
| 7 | Murphy, 2014 | 39 | 24 | 15 | 16.4 (11-17.9) | 8.4 (2.2-20.8) | Fc, P, Tp, T | 8.4 (1.7-27.1) | Level IV | Case series | ✓ | ✓ | ✓ | |||||
| 8 | Niethammer, 2016 | 40 | 24 | 16 | 16.0 (11-19) | 5.3 (1.5-10.5) | Fc, P | 3.0 | Level IV | Case series | ✓ | ✓ | ✓ | |||||
| 9 | Ogura, 2017 | 27 | 13 | 14 | 15.9 (13-17) | 6.2 (2.0-23.4) | Fc, P, Tp, T | 9.6 (2-19) | Level IV | Case series | ✓ | ✓ | ✓ | |||||
| 10 | Salzmann, 2012 | 10 | 8 | 2 | 14.1 (9-16) | 1.2 | Fc, P, Tp, T | 3.5 | Level IV | Case series | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| 11 | Sasaki, 2012 | 11 | 9 | 2 | 13.7 (12-16) | 2.7 (1-4.5) | Fc | 2.2 (0.5-5) | Level IV | Case series | ✓ | ✓ | ✓ | |||||
| 12 | Steadman, 2015 | 26 | 12 | 14 | 16.6 (12-18.9) | 1.9 (0.4-5.7) | Fc, P, T | 5.8 (2-13.3) | Level IV | Case series | ✓ | ✓ | ✓ |
ACI = autologous chondrocyte implantation; IKDC, International Knee Documentation Committee; MFX = microfracture; OATS = osteochondral autograft transplantation system; OCA = osteochondral allograft transplantation; VAS = visual analogue scale.