Table 3.

Safety and tolerability parameters evaluated during the study period

	Dose rhNGF eye drop (µg/mL)	Baseline (from day −15 to day −1)	Day 1	Day 8±1	Day 29±1 (end of treatment)	Day 56±4 (end of follow-up)
IOP: mm Hg (mean±SD)	20	15.9±1.9	15±1.6*	14.1±1.6*	14.4±1.9*	14.2±2.7*
	4	12.7±2.3	12.9±2.4	13.2±2.9	14.1±2.4	13.6±2.5
Frequency of AT use: number of daily administration (mean±SD)	20	2.9±3.85	–	1.81±1.9	2.13±2.81	2.87±2.96
	4	3.3±1.89	–	1.083±1.54	1.27±1.33	2.46±2.86
BCVA: number of letters ETDRS (mean±SD)	20	85.5±5.5	86.1±5.1	85.9±5.1	86.7±4.4	86.6±3.7
	4	74.6±21.9	76.2±20.9	78±19.4*	78.9±15.4*	81.3±13.3*
VAS: Foreign body sensation mm (mean±SD)	20	48.0±27.8	29.6±26.5*	22.8±25.3*	16.6±24.7*	17.4±25.8*
	4	48.3±26.2	47.1±28.6	28.4±27.4*	18.7±19.5*	18.4±25.9*
VAS: Burning/stinging mm (mean±SD)	20	48.2±23.6	26.9±24.8*	22.4±24.2*	15.5±24.7*	18.0±25.7*
	4	46.8±28.6	39.4±28.6	33.1±28.6	21.2±23.4*	16.9±23.6*
VAS: itching mm (mean±SD)	20	43.3±23.5	28.7±26.2*	19.6±18.1*	12.7±21.0*	17.4±26.4*
	4	54±26.9	40±30*	29.9±29.9*	19.1±22.4*	18.8±21.9*
VAS: pain mm (mean±SD)	20	40.7±29.5	21.5±24.6*	25.3±34.2*	16.3±28.2*	15.8±27.0*
	4	29.5±26.2	27±25	25.4±27.8	16.1±24.9*	12.6±20.3*
VAS: Sticky feeling mm (mean±SD)	20	30.2±25.6	21.0±22.0*	18.5±21.9*	17.5±28.9*	17.1±30.1*
	4	38.8±26.7	37.4±30.9	21.9±27.3*	16.6±26.4*	16.2±23.6*
VAS: Blurred vision mm (mean±SD)	20	58.7±22.8	34.7±25.6*	28.8±28.5*	17.7±26.5*	19.3±27.6*
	4	54.5±31.8	47.5±31.7	37.3±32.5*	25.7±28*	26.1±27.9*
VAS: photophobia mm (mean±SD)	20	59.9±20.8	38.9±30.6*	32.9±30.5*	28.4±31.2*	27.7±32.3*
	4	48.1±31.6	53.1±32.5	37.3±31.7	29.8±34.8*	25.1±26.8*

*P<0.05 Wilcoxon signed-rank test.

AT, artificial tears; BCVA, best-corrected visual acuity;IOP, intraocular pressure; VAS, Visual Analogue Scale.