Table 5.
Δ9-Tetrahydrocannabinol Pharmacokinetic Parameters of Cmax, Tmax, t1/2, AUC0–24, Vz/F and Cl/F Were Determined from Noncompartmental Analysis
| Treatment | Cmax (ng·mL−1) | Tmax (hours) | t1/2 (hours) | AUC0–24 (ng·h·mL−1) | VZ/F (L) | Cl/F (L·h−1) |
|---|---|---|---|---|---|---|
| A | 1.86±1.01 | 1.9±1.1 | 1.6±1.3 | 3.13±1.89 | 66.1±27.5 | 66.4±27.4 |
| B | 2.60±2.33 | 6.6±2.6* | 2.8±2.0 | 8.75±7.38* | 41.0±34.7* | 41.1±34.8* |
| C | 4.24±2.53 | 1.8±1.4 | 2.6±2.1 | 8.71±5.95 | 70.5±26.2 | 70.4±26.2 |
| D | 4.51±2.54 | 6.6±2.8* | 2.6±1.9 | 17.60±9.22* | 44.3±28.8* | 44.1±28.7* |
Data are represented as mean±SD and * denotes statistical significance between the same THC dosages (Treatment A compared with Treatment B and Treatment C compared with Treatment D). Where Treatment A is 5 mg THC fasted, Treatment B is 5 mg THC and a high-fat meal, Treatment C is 10 mg THC fasted, and Treatment D is 10 mg THC and a high-fat meal.