Table 6.
11-Hydroxy-Tetrahydrocannabinol Pharmacokinetic Parameters of Cmax, Tmax, tlag, Clast, t1/2 and AUC0–24 Were Determined from Noncompartmental Analysis
| Treatment | Cmax (ng·mL−1) | Tmax (hours) | Tlag (hours) | Clast (ng·mL−1) | t1/2 (hours) | AUC0–24 (ng·h·mL−1) |
|---|---|---|---|---|---|---|
| A | 2.86±1.64 | 1.9±1.1 | 1.2±1.6 | 0.12±0.02 | 4.3±2.6 | 7.16±4.70 |
| B | 1.91±1.38 | 6.8±2.6* | 4.0±2.4* | 0.18±0.13 | 4.2±1.9 | 9.40±5.70* |
| C | 5.10±2.44 | 2.0±1.4 | 0.9±1.5 | 0.14±0.048 | 5.8±3.0 | 14.72±7.33 |
| D | 3.40±1.69 | 6.7±2.6* | 3.3±1.5* | 0.23±0.15 | 6.3±2.4 | 17.74±6.64* |
Data are represented as mean±SD and * denotes statistical significance between the same THC dosages (Treatment A compared with Treatment B and Treatment C compared with Treatment D). Where Treatment A is 5 mg THC fasted, Treatment B is 5 mg THC and a high-fat meal, Treatment C is 10 mg THC fasted and Treatment D is 10 mg THC and a high-fat meal.