Table 7.
A Summary of How an Orally Ingested Encapsulated Δ9-Tetrahydrocannabinol Extract's Pharmacokinetic Parameters for Δ9-Tetrahydrocannabinol and 11-Hydroxy-Tetrahydrocannabinol Were Altered by the Presence of a High-Fat Meal in Comparison to Consumption under a Fasting State
| PK parameters | High-fat meal vs. fasted state | |
|---|---|---|
| THC | Cmax (ng·mL−1) | No change |
| Tmax (hours) | ↑ | |
| t1/2 (hours) | No change | |
| AUC0–24 (ng·h·mL−1) | ↑ | |
| VZ/F (L) | ↓ | |
| Cl/F (L·h−1) | ↓ | |
| 11-OH-THC | Cmax (ng·mL−1) | No change |
| Tmax (hours) | ↑ | |
| Tlag (hours) | ↑ | |
| Clast (ng·mL−1) | No change | |
| t1/2 (hours) | No change | |
| AUC0–24 (ng·h·mL−1) | ↑ |
11-OH-THC, 11-hydroxy-tetrahydrocannabinol.