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. 2019 Dec 9;4(4):231–239. doi: 10.1089/can.2019.0030

FIG. 2.

FIG. 2.

2-LG is a partial agonist of the CB1 receptor. (A) Concentration–response graph of 2-LG in the presence of 100 nM JZL195, 2-LG in the absence of JZL195, and 2-LG in the presence of both 100 nM JZL195 and 2.5 μM AM251. Data are presented as mean±SEM of pooled independent experiments (n=2–17 independent experiments) with eight replicates in each experiment. Statistical significance of 2-LG responses in the absence of JZL195 compared to its control, and 2-LG responses in the presence of JZL195 compared to JZL195 only control were established with one-way ANOVA and Dunnett's post-test. (B) Comparison of the maximal responses of 2LG (25 μM), ACEA (5 μM), 2-AG (25 μM), and AEA (5 μM) in the presence and absence of 2.5 μM AM251. One hundred nanomolar JZL195 was included only in 2-LG wells and experiments. Data are presented as mean±SEM of pooled independent experiments (2-LG n=17; ACEA n=13; 2-AG n=4; and ACEA n=7) with eight replicates in each experiment. Significance between groups was established with one-way ANOVA and Bonferroni's multiple comparison post-test. ***p<0.001. 2-LG, 2-linoleoylglycerol.