Table 3.
Differences in mpMRI and pathology characteristic between TZ and PZ PCa index lesions detected by mpMRI.
| Clinical characteristics | Peripheral zone, (n=248) | Transition zone, (n=75) | P value |
|---|---|---|---|
| PSAa (ng/ml), median (IQRb) | 5.90 (4.50 – 8.15) | 7.70 (5.30 – 12.10) | 0.001 |
| PSA density (ng/ml/cc), median (IQR) | 0.17 (0.12 – 0.23) | 0.18 (0.13 – 0.31) | 0.064 |
| Prostate volume (cm3), median (IQR) | 35.00 (28.30 – 44.20) | 39.90 (31.00 – 47.00) | 0.155 |
| Biopsy Gleason | 0.386 | ||
| 3+3 | 59 (24.2%) | 14 (18.7%) | |
| 3+4 | 85 (34.8%) | 33 (44.0%) | |
| 4+3 | 31 (12.7%) | 6 (8.0%) | |
| Others | 73 (29.4%) | 22 (29.3%) | |
| mpMRI tumor volume (cm3), median (IQR) | 0.30 (0.16 – 0.71) | 0.52 (0.25 – 1.74) | 0.001 |
| PI-RADSv2c category | <0.001 | ||
| 2 | 13 (5.26%) | 1 (1.37%) | |
| 3 | 33 (13.36%) | 24 (32.88%) | |
| 4 | 133 (53.85%) | 16 (21.92%) | |
| 5 | 68 (27.53%) | 32 (43.84%) | |
| Pathology diameter (cm), median (IQR) | 2.00 (1.50 – 2.80) | 2.40 (1.90 – 3.40) | 0.003 |
| Pathology prostate weight (gm), median (IQR) | 42.00 (34.00 – 52.00) | 41.45 (33.30 – 51.40) | 0.801 |
| Pathology Gleason score | 0.317 | ||
| 3+3 | 21 (8.47%) | 9 (12.00%) | |
| 3+4 | 126 (50.81%) | 44 (58.67%) | |
| 4+3 | 64 (25.81%) | 13 (17.33%) | |
| Others | 37 (14.92%) | 9 (12.00%) | |
| Pathology Staging | 0.055 | ||
| 2 | 143 (57.7%) | 48 (64.0%) | |
| 3a | 76 (30.65%) | 25 (33.33%) | |
| 3b | 29 (11.69%) | 2 (2.67%) | |
| Positive Surgical Margins | 34 (13.7%) | 11 (14.7%) | 0.834 |
a
Prostate Specific Antigen,
b
Interquartile Range,
c
Prostate Imaging – Reporting and Data System version 2