Table 4.
Differences in mpMRI and pathology characteristic of TZ and PZ PCa in false negative and false positive index lesions.
| Pathology characteristics | FNa PZb (n=73) | FN TZc (n=29) | P value |
|---|---|---|---|
| Biopsy Gleason, | 0.595 | ||
| 3 +3, | 26 (35.6%) | 13 (44.8%) | |
| 3+4, | 30 (41.1%) | 12 (41.4%) | |
| 4+3, | 4 (5.5%) | 2 (6.9%) | |
| Others | 13 (17.8%) | 2 (6.9%) | |
| Pathology tumor diameter (cm), median (IQRd) | 1.40 (0.80–2.00) | 1.60 (1.05–2.60) | 0.176 |
| Pathology prostate weight (gm), median (IQR) | 49.5 (36.3–71.8) | 41.9 (32.6–61) | 0.222 |
| Pathology Gleason score | 0.298 | ||
| 3 +3, | 19 (26%) | 9 (31%) | |
| 3+4, | 41 (56.2%) | 15 (51.7%) | |
| 4+3, | 7 (9.6%) | 5 (17.2%) | |
| Others, | 6 (8.2%) | 0 (0%) | |
| Pathology Staging | 0.488 | ||
| 2, | 66 (90.4%) | 25 (86.2%) | |
| 3a, | 7 (9.6%) | 4 (13.8%) | |
| 3b, | 0 (0%) | 0 (0%) | |
| mpMRI characteristics | FPe PZ (n=72) | FP TZ (n=38) | P value |
| Prostate volume (cm3), median (IQR) | 37.0 (30.4–48.9) | 49.8 (35.0–62.9) | 0.021 |
| MRIf tumor volume (cm3), median (IQR) | 0.18 (0.07–0.40) | 0.23 (0.09–0.38) | 0.519 |
| PI-RADSv2g category | 0.033 | ||
| 2, | 13 (18.1%) | 15 (39.5%) | |
| 3, | 34 (47.2%) | 18 (47.4%) | |
| 4, | 20 (27.8%) | 4 (10.5%) | |
| 5, | 5 (6.9%) | 1 (2.6%) |
a
False Negative,
b
Peripheral Zone,
c
Transition Zone,
d
Interquartile Range,
e
False Positive,
f
Magnetic Resonance Imaging,
g
Prostate Imaging – Reporting and Data System version 2