Figure 4.

DS-Cav1 stabilized RSV F glycoproteins have higher flexibility at the apical region. (A) Worm diagrams of the RSV F trimers with thickness proportional to B factor values. The figures were prepared with PyMOL from crystal structures of B18537, B9320 (5UDE), and A2 (4MMU). The positions of antigenic sites Ø and III on the front face are marked with red and pale-yellow contours on the diagram of the B18537 structure. (B) Pairwise RMSD between the 3 structures at 2 antigenic sites with the corresponding sequence identity of the epitope residues. RMSD was calculated based on Cα atoms.