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. 2019 Dec 11;4(2):294–323. doi: 10.20411/pai.v4i2.338

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© Pathogens and Immunity 2019

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Figure 7. — Prefusion-stabilized RSV B18537 DS-Cav1 F elicits high neutralization titers against both subtypes A and B viruses. (A) Mice were immunized with either DS-Cav1 or postfusion B18537 F glyco-protein at weeks 0 and 3. Serum samples were taken at week 5. (B) Mouse sera were assayed for neutralization against subtype A and B strains. Each dot represents the serum titer from a single mouse. Average titer of each group is marked with a line and also labeled on the horizontal axis. (C) Sera from mice immunized with RSV B18537 F prefusion DS-Cav1 or postfusion immunogen were assessed for binding to the immobilized RSV B18537 F DS-Cav1, postfusion, DS-Cav1 bound by MPE8, or DS-Cav1 bound by D25. Average response of each group is marked with a red line. Statistical analyses in (B) and (C) were calculated by Mann-Whitney 2-tailed t test, ****: P < 0.001.