Table 2. GRADE quality of evidence for the comparative efficacy of antimalarial.
| Treatment comparison |
Direct estimate; OR (95% CI) | Quality of evidence |
Indirect estimate; OR (95% CI) |
Quality of evidence |
Network estimate; OR (95% CI) |
Quality of evidence |
|---|---|---|---|---|---|---|
| DHP vs AL | 1.29 (0.74 to 2.23) 1 fewer per 1,000 (from 2 fewer to 1 fewer) |
⨁◯◯◯d,e VERY LOW |
2.5 (1.08 to 5.8) 3 fewer per 1,000 (from 6 fewer to 1 fewer) |
⨁⨁◯◯a LOW |
2.5 (1.08 to 5.8) 3 fewer per 1,000 (from 6 fewer to 1 fewer) |
⨁⨁◯◯a LOW |
| DHP vs ASCQ | NA | NA | 11.21 (3.40 to 36.89) |
⨁◯◯◯ VERY LOW |
11.21 (3.4–36.89) 11 fewer per 1,000 (from 37 fewer to 3 fewer) |
⨁◯◯◯a,b,c VERY LOW |
| DHP vs CQ | NA | NA | 16.54 (5.02–54.56) |
⨁⨁◯◯ LOW |
16.54 (5.02 to 24.56) 17 fewer per 1,000 (from 25 fewer to 5 fewer |
⨁⨁◯◯a,b LOW |
| DHP vs ASSP | NA | NA | 0.01 (0.00–0.04) | ⨁⨁◯◯ LOW |
0.01 (0.00 to 0.04) 0 fewer per 1,000 (from—to 0 fewer) |
⨁⨁◯◯a,b LOW |
| ASCQ vs AL | NA | NA | 0.22 (0.06–0.79) | ⨁⨁◯◯ LOW |
0.22 (0.06–0.79) 0 fewer per 1,000 (from 1 fewer to 0 fewer) |
⨁⨁◯◯a LOW |
| ASAQ vs AL | NA | NA | 5.55 (0.26–119.75) | ⨁◯◯◯ VERY LOW |
5.55 (0.26–119.75) 6 fewer per 1,000 (from 120 fewer to 0 fewer) |
⨁◯◯◯a,b,d VERY LOW |
CI: Confidence interval; OR: Odds ratio; Explanations: a. studies at unclear and high risk of bias; b. wide predictive interval; c. very wide CI; d. wide 95%CI and it crossed a null value; e: a singular study at high risk of bias; f. a singular study