Table 5. Hazard ratios from the multiple-variable Cox model for the TCGA lung cancer (Caucasian patients).

	Multivariate analysis			Multivariate analysis
	HR	P-value		HR	P-value
LUAD:
H63D variant	0.71 (0.38–1.32)	0.2803	C282Y variant	1.70 (0.70–4.23)	0.2409
AgeAtDiagnosis	1.00 (0.98–1.04)	0.5381	AgeAtDiagnosis	1.00 (0.98–1.05)	0.4285
Tumor stage	3.60 (1.93–6.55)	<0.0001	Tumor stage	4.20 (2.26–7.63)	<0.0001
Smoking	2.00 (1.08–3.55)	0.0275	Smoking	1.90 (1.03–3.40)	0.0392
LUSC:
H63D variant	1.80 (0.59–5.24)	0.3084	C282Y variant	0.32 (0.13–0.78)	0.0130
AgeAtDiagnosis	1.00 (0.96–1.06)	0.6639	AgeAtDiagnosis	1.00 (0.97–1.06)	0.6231
Tumor stage	2.50 (1.10–5.68)	0.0279	Tumor stage	2.40 (1.08–5.51)	0.0316
Smoking	0.82 (0.36–1.84)	0.6286	Smoking	0.58 (0.24–1.42)	0.2349

LUAD (lung adenocarcinoma)

LUSC (lung squamous cell carcinoma)

HR (hazard ratio)

Covariates: Age at diagnosis (continuous), tumor stage (two categories, 3&4 vs 1&2), and smoking status (ever smoked vs never smoked)