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. 2019 Dec 19;14(12):e0226566. doi: 10.1371/journal.pone.0226566

Table 3. Deaths organized by underlying cause of death and by HCV serological status.

General Cause of Death HCV+* HCV-** HR adjusted# CI 95% p-Value
N = 2,652 N = 5,782
All liver related deaths 75 6 24.06 (10.45–55.39) <0.001
HCV 23 0 - -
Other viral hepatitis infection 4 1 7.10 (0.78–64.52) 0.082
Liver Disease 30 4 15.22 (5.34–43.37) <0.001
Liver Cancer 18 1 29.52 (3.93–221.73) 0.001
Non-Hepatic Cancer 28 48 1.00 (0.62–1.60) 0.992
Cardiovascular-Related Causes 17 29 1.03 (0.56–1.88) 0.931
Pulmonary Causes 9 8 2.32 (0.89–6.06) 0.086
Trauma/Suicide 32 45 1.66 (1.05–2.61) 0.029
Trauma 32 40 1.86 (1.17–2.97) 0.009
Suicide 0 5 - -
Drugs/Alcohol 2 0 - -
Neurological Diseases 7 13 0.90 (0.36–2.28) 0.830
Infection 20 14 2.75 (1.38–5.47) 0.004
Other/Unknown 19 27 1.39 (0.77–2.52) 0.277
Kidney Diseases 3 4 1.26 (0.28–5.72) 0.761
Diabetes Mellitus 1 5 0.33 (0.38–2.87) 0.315
Other 15 18 1.74 (0.87–3.47) 0.117
All Deaths 209 190 2.15 (1.76–2.62) <0.001

* HCV +: HCV seropositive only.

** HCV-: Seronegative for all infections tested.

#HR: HazardRatio adjusted by sex, age. Type of donation and type of donor dropped from final adjusted models. Male sex and increasing age acted as positive confounders on both adjusted models. CI: Confidence Interval