Table 2. Weights of the topological profiles of the three cohorts when using only late-stage atrophy data are more uncertain and overlap more.

The table reports the weights for each network metric, grouped per topological descriptor.

Topological descriptors	Network metrics	AD	PPMS	HA
	Betweenness centrality	0.15 (0.11)	0.11 (0.09)	0.05 (0.02)
Centrality	Closeness centrality	0.01 (0.03)	0.06 (0.07)	0.01 (0.02)
	Weighted degree	0.03 (0.04)	0.11 (0.08)	0.09 (0.05)
	Clustering coefficient	0.07 (0.10)	0.11 (0.15)	0.03 (0.02)
Segregation	Inverse degree	0.06 (0.06)	0.12 (0.09)	0.06 (0.06)
	Inverse clustering	0.09 (0.08)	0.25 (0.22)	0.01 (0.04)
Network proximity	Shortest path	0.30 (0.22)	0.05 (0.05)	0.02 (0.04)
Cortical proximity	Spatial distance	0.12 (0.09)	0.15 (0.09)	0.15 (0.09)
Constant progression	Constant term	0.04 (0.05)	0.10 (0.07)	0.33 (0.21)