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. Author manuscript; available in PMC: 2020 Jan 4.
Published in final edited form as: Lab Invest. 2019 Jul 4;100(1):135–146. doi: 10.1038/s41374-019-0283-0

Figure 1.

Figure 1

A schematic overview of the Cas9 enrichment workflow showing the wet laboratory (A) and informatics steps (B). Cleavage reactions for (+) and (−) strand guide RNAs are performed separately to prevent interference.