Table 2.
Retrospective view of dendritic spine density: dorsal horn sensory neurons versus ventral horn motor neurons
| Treatment arm | Dorsal horn sensory neuronsa | Ventral horn motor neurons |
|---|---|---|
| Total spine density | ||
| Burn + anti‐Pak1 (Day 6) | 2.8 ± 0.4b, c | 0.59 ± 0.19c |
| Burn + DMSO (Day 6) | 3.5 ± 0.6b | 1.11 ± 0.32b |
| Burn + anti‐Pak1 (Day 10) | 2.9 ± 0.6b | 0.59 ± 0.31c |
| Burn + DMSO (Day 10) | 3.1 ± 1.1b | 1.0 ± 0.17b |
| Sham | 2.4 ± 0.4 | 0.60 ± 0.13 |
| Thin spine density | ||
| Burn + anti‐Pak1 (Day 6) | 2.4 ± 0.3b, c | 0.53 ± 0.16c |
| Burn + DMSO (Day 6) | 2.9 ± 0.7b | 1.0 ± 0.26b |
| Burn + anti‐Pak1 (Day 10) | 2.5 ± 0.4b | 0.55 ± 0.29c |
| Burn + DMSO (Day 10) | 2.6 ± 0.9b | 0.86 ± 0.17b |
| Sham | 2.1 ± 0.4 | 0.56 ± 0.13 |
| Mushroom spine density | ||
| Burn + anti‐Pak1 (Day 6) | 0.43 ± 0.2b, c | 0.05 ± 0.05 |
| Burn + DMSO (Day 6) | 0.58 ± 0.2b | 0.11 ± 0.08b |
| Burn + anti‐Pak1 (Day 10) | 0.47 ± 0.2b, c | 0.04 ± 0.05 |
| Burn + DMSO (Day 10) | 0.48 ± 0.3b | 0.1 ± 0.07b |
| Sham | 2.8 ± 0.4 | 0.03 ± 0.02 |
Summary table showing the retrospective datasets of burn injury on ventral horn motor neuron dendritic spine density as compared with published data on sensory neurons following second‐degree burn injury (Guo et al., 2018). Dendritic spine density is measured as number of spines per 10 mm dendritic branch length. In all comparisons, dorsal horn exhibited a greater density of dendritic spines than compared with ventral horn neurons (*p < .01).
Datasets from previous publication Guo et al., 2018
Denotes statistically significant increase in dendritic spine density following burn injury as compared with Sham control (no burn) data.
Denotes a statistically significant effect of anti‐Pak1 (romidepsin) drug treatment as compared with DMSO treatment, in burn‐injured animals within the same time point (i.e., Day 6 or Day 10 post drug withdrawal).