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. 2019 Oct 8;50(1):12–21. doi: 10.4070/kcj.2019.0288

Figure 2. Mechanisms for the ADRCs-mediated angiogenesis in ischemic tissues.

Figure 2

Subcutaneous adipose tissue is isolated from patient with CLI. ADRCs are isolated by the adipose tissues and directly implanted into the patient's own ischemic skeletal muscles. Implanted ADRCs release angiogenic cytoines/chemokines, extracellular microvesicles including miRNAs that stimulate local angiogenic response. A part of ADRCs differentiated into pericytes and support the angiogenesis.

ADRC = adipose-derived regenerative cell; CLI = critical limb ischemia; miRNA = microRNA.