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. 2019 Dec 13;10:1274. doi: 10.3389/fgene.2019.01274

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Copyright © 2019 Gao, Zhou and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-30b-3p inhibited the PI3K/Akt pathway in HCC cells. (A) IHC staining of TRIM27 and p-Akt in HCC tissues and their matched non-carcinoma tissues. (B,C) Western blotting was used to detect the protein levels of TRIM27, Akt, and p-Akt in HCC cells after transfection with indicated transfections. (D) The proposed mechanism indicated that miR-30b-3p suppressed the PI3K/Akt pathway by downregulating TRIM27 in HCC cells. All the experiments were repeated three times. ^*, p < 0.05; ^**, p < 0.01; ^***, p < 0.001; ns, not significant.