Table. 2.
Extracellular purines and metabolic reprogramming
| Receptors | Cell types | Biological process | Metabolic alterations | Reference |
|---|---|---|---|---|
| P1 receptors | ||||
|
ADORA2A ADORA2B |
Macrophage | Activation and inflammatory response | Glycolytic flux, glycolysis, and OXPHOS | [22, 71, 72] |
| Unknown | DCs, tumor-associated macrophages | Immunosuppressive function, pro-tumor effects | Glycolysis and OXPHOS | [38, 74] |
| ADORA2A | Brown adipocytes | Brown adipose tissue activation, thermogenesis | Lipolysis | [73] |
| ADORA2B | Erythrocytes | Oxygen release | Glycolytic flux and glycolysis | [30, 31] |
| ADORA2B | Hematopoietic progenitor cells | Stress hematopoiesis | Glycolytic flux and glycolysis | [77] |
| P2 receptors | ||||
| P2X7R | HEK293 cells | Cell growth | Glycolysis and glycogen stores | [92] |
| P2YRs | WA and 3T3-L1 cells | Unknown | Glycolytic flux and metabolism | [93, 94] |
OXPHOS, oxidative phosphorylation