Fig. 2.
In vitro uptake of 64Cu-ATSM and 64Cu-Cl2 in tumor cells as a function of the degree of oxygenation. Quantification of cell retention of 64Cu-ATSM or 64Cu-Cl2 in normoxic (21% O2), moderate hypoxia (5% and 21% O2), or severe hypoxia (0.5% and 0.2% O2) for raw values (a) or normalized values relative to normoxic condition (b). Mean ± SD, n = 3 different cell cultures per condition. Tukey’s HSD test after significant two-ways ANOVA (group and time factors) was used. For comparison between 64Cu-ATSM and 64Cu-Cl2 for each oxygen condition, statistical significance was *p < 0.05. Statistical significances relative to normoxia were § < 0.05 for 64Cu-ATSM and #p < 0.05 for 64Cu-Cl2