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Homology-directed repair pathway determination and its favorable cell contexts. Activation of the MRN complex and P53/SOG1 triggers the activation of cell cycle checkpoint proteins such as CDKB1 (G2/M checkpoint) and CYCB1 (S phase checkpoint) or NAC-type transcription factors ANAC044 and ANAC085 (S/G2 checkpoints) or WEE1 kinase for cell cycle arrest
