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. 2019 Nov 22;63(6):727–741. doi: 10.1042/EBC20190033

Figure 2. Possible scenarios by which DNA methylation could impact TF binding.

Figure 2

(A) TFs sensitive to DNA methylation are repressed from binding by mCpGs within their motifs, causing steric hindrance or alteration of the DNA shape. (B) Methyl-binding domain proteins (MBDs) recognize mCpGs in a sequence-independent manner. TFs bind sequence motifs containing mCpGs through direct affinity. (C) TFs insensitive to DNA methylation bind their motifs regardless of the DNA methylation status of the surrounding region.