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. 2019 Nov 22;63(6):727–741. doi: 10.1042/EBC20190033

Figure 3. Proportion of TFs having CpGs in their motifs.

Figure 3

The majority of TFs (70%) do not have prominent CpGs in their motifs whereas 26.8% have one CpG and 3.2% have two CpGs. We used 579 position weight matrices from the vertebrates JASPAR CORE 2018 TF motifs [5] assuming that these represent well all 1600 TFs [1]. The presence of prominent CpGs in TF motifs was calculated by counting consecutive C and G positions with more than 0.5 frequency. JASPAR motif IDs: NRF1: MA0596.1; KAISO: MA0527.1; MYC: MA0147.3; USF1: MA0093.3; SP1: MA0079.3; CREB1: MA0018.3; CEBPB: MA0466.2; CEBPA: MA0102.3; KLF4: MA0039.3; GATA3: MA0037.3; REST: MA0138.2; FOXA1: MA0148.3; POU5F1: MA1115.1; YY1: MA0095.2. Abbreviation: USF1, transcription factor CP2-like protein 1.