Table 2. Overall and subgroup analyses for ANRIL polymorphisms and CAD.
| Polymorphisms | Population | Sample size | Dominant comparison | Recessive comparison | Additive comparison | Allele comparison | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | |||
| rs1333040 | Overall | 2285/6182 | <0.0001 | 1.30 (1.17–1.44) | <0.0001 | 0.71 (0.62–0.82) | 0.12 | 0.85 (0.69–1.04) | <0.0001 | 1.25 (1.16–1.34) |
| East Asian | 1009/2227 | 0.03 | 1.37 (1.04–1.80) | 0.18 | 0.82 (0.61–1.09) | 0.06 | 0.76 (0.57–1.01) | 0.001 | 1.22 (1.08–1.38) | |
| rs1333049 | Overall | 3090/4062 | 0.02 | 0.81 (0.67–0.96) | 0.08 | 1.24 (0.98–1.57) | 0.35 | 1.05 (0.95–1.15) | 0.02 | 0.86 (0.76–0.98) |
| Caucasian | 1689/1670 | 0.37 | 0.85 (0.60–1.20) | 0.93 | 1.02 (0.69–1.51) | 0.32 | 1.10 (0.91–1.31) | 0.59 | 0.93 (0.72–1.20) | |
| East Asian | 1107/2102 | 0.16 | 0.82 (0.61–1.09) | 0.02 | 1.19 (1.03–1.38) | 0.31 | 1.07 (0.94–1.20) | 0.06 | 0.87 (0.75–1.01) | |
| rs2383206 | Overall | 3055/11457 | 0.60 | 0.91 (0.64–1.29) | 0.33 | 1.18 (0.84–1.65) | 0.36 | 0.90 (0.72–1.13) | 0.45 | 0.91 (0.72–1.16) |
| Caucasian | 1286/9613 | <0.0001 | 0.61 (0.53–0.71) | 0.02 | 1.71 (1.08–2.71) | 0.61 | 0.88 (0.53–1.45) | 0.0002 | 0.68 (0.56–0.84) | |
| West Asian | 409/484 | 0.006 | 1.49 (1.12–1.99) | 0.19 | 0.47 (0.15–1.46) | 0.83 | 1.08 (0.53–2.19) | 0.002 | 1.36 (1.12–1.65) | |
| rs2383207 | Overall | 4712/8589 | 0.09 | 1.29 (0.96–1.72) | 0.66 | 0.94 (0.73–1.22) | 0.004 | 0.80 (0.69–0.93) | 0.15 | 1.17 (0.95–1.45) |
| Caucasian | 1506/4332 | 0.97 | 1.02 (0.42–2.47) | 0.58 | 1.21 (0.62–2.35) | 0.48 | 0.88 (0.61–1.26) | 0.94 | 0.98 (0.55–1.75) | |
| East Asian | 2669/3681 | 0.0003 | 1.45 (1.18–1.79) | 0.03 | 0.83 (0.71–0.98) | <0.0001 | 0.77 (0.69–0.85) | 0.0005 | 1.28 (1.11–1.48) | |
| West Asian | 537/576 | 0.08 | 1.24 (0.97–1.58) | 0.57 | 0.89 (0.61–1.32) | 0.15 | 0.84 (0.65–1.07) | 0.12 | 1.16 (0.96–1.39) | |
| rs10757274 | Overall | 2299/10973 | 0.89 | 0.98 (0.69–1.39) | 0.27 | 1.23 (0.85–1.76) | 0.15 | 0.86 (0.70–1.06) | 0.89 | 0.98 (0.69–1.39) |
| Caucasian | 1286/9613 | <0.0001 | 0.62 (0.54–0.72) | 0.03 | 1.92 (1.08–3.42) | 0.54 | 0.83 (0.46–1.50) | 0.001 | 0.65 (0.50–0.84) | |
| West Asian | 722/975 | 0.003 | 1.36 (1.11–1.67) | 0.17 | 0.84 (0.66–1.08) | 0.08 | 0.84 (0.69–1.02) | 0.04 | 1.28 (1.01–1.62) | |
| rs10757278 | Overall | 1907/1987 | 0.81 | 1.09 (0.63–1.87) | 0.72 | 1.10 (0.67–1.81) | 0.24 | 0.83 (0.61–1.13) | 0.87 | 1.03 (0.70–1.52) |
| Caucasian | 1286/1278 | <0.0001 | 0.60 (0.50–0.73) | 0.008 | 1.95 (1.19–3.19) | 0.61 | 0.89 (0.57–1.39) | <0.0001 | 0.65 (0.52–0.81) | |
| West Asian | 409/477 | 0.06 | 1.33 (0.98–1.80) | 0.35 | 0.63 (0.24–1.66) | 0.54 | 0.92 (0.70–1.20) | 0.22 | 1.37 (0.83–2.27) | |
The values in bold represent that there are statistically significant differences between cases and controls. P-values ≤0.05 were considered to be statistically significant. Abbreviation: MI, myocardial infarction.