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. 2019 Dec 17;39(12):BSR20192909. doi: 10.1042/BSR20192909

Figure 4. HQQR alleviated LVH and improved mitochondrial function by SIRT1/PGC-1α deacetylation pathway.

Figure 4

(A) The ATP content was detected in each group (n = 4 per group). (B) The mtDNA copy number was assayed in each group (n = 4 per group). (C) The protein expression of SIRT1, PGC-1α, NRF1 and TFAM was determined by immunoblotting. (D) Western blot quantification of SIRT1, PGC-1α, NRF1 and TFAM levels (n = 4 per group). (E) Immunoprecipitation and Western blot analysis of PGC-1α acetylation in each group. (F) The ratio of acetylated PGC-1α to precipitated PGC-1α protein was calculated (n = 4 per group). Data are mean ± SD. *P < 0.05, **P < 0.01 compared with WKY-ND; +P < 0.05, ++P < 0.01 compared with OBH-HF.