Table 3.
Comparisons of cytokine levels in aqueous humor among nAMD subtypes and controls.
| Category | nAMD | Control | P value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Subtype | Type 1 | Type 2 | PCV | 20 | Among 4 groups | Control vs. | Type 1 vs. | Type 2 vs. | |||
| N | 21 | 15 | 25 | Type 1 | Type 2 | PCV | Type 2 | PCV | PCV | ||
| Value | Median | ||||||||||
| logMAR VA | 0.222 | 1.046 | 0.222 | 0.301 | 0.004** | 0.646 | 0.292 | 0.574 | 0.005** | 1.000 | 0.004** |
| CRT | 259 | 395 | 260 | 266 | 0.002** | 0.999 | 0.007** | 0.972 | 0.051 | 0.698 | 0.002** |
| Gender (M/F) | 16/5 | 9/6 | 15/10 | 8/12 | 0.134 | 0.042* | 0.407 | 0.301 | 0.501 | 0.395 | 0.739 |
| PDGF-BB | 0 | 0 | 0 | 0 | — | — | — | — | — | — | — |
| IL-1β | 0 | 0 | 0 | 0 | — | — | — | — | — | — | — |
| IL-1ra | 0 | 0 | 0 | 0 | 0.404 | 0.761 | 0.344 | 0.573 | 0.764 | 0.961 | 0.950 |
| IL-2 | 0 | 0 | 0 | 0 | — | — | — | — | — | — | — |
| IL-4 | 0 | 0 | 0 | 0 | 0.384 | 0.733 | 0.821 | 0.676 | — | — | — |
| IL-5 | 0 | 0 | 0 | 0 | — | — | — | — | — | — | — |
| IL-6 | 4.34 | 9.24 | 4.27 | 40.5 | 0.001** | 0.006** | 0.046* | 0.002** | 0.777 | 0.994 | 0.673 |
| IL-7 | 12.0 | 10.2 | 7.97 | 10.9 | 0.031* | 0.995 | 0.989 | 0.036* | 0.999 | 0.175 | 0.105 |
| IL-8 | 5.68 | 6.19 | 5.29 | 5.72 | 0.759 | 0.872 | 0.976 | 0.971 | 0.999 | 0.767 | 0.936 |
| IL-9 | 0 | 0 | 0 | — | 0.427 | 0.733 | 0.995 | 0.676 | 0.635 | — | 0.566 |
| IL-10 | 0 | 0 | 0 | 0 | — | — | — | — | — | — | — |
| IL-12 | 9.22 | 10.6 | 0 | 9.80 | 0.170 | 0.961 | 0.985 | 0.273 | 0.807 | 0.655 | 0.178 |
| IL-13 | 1.54 | 2.86 | 1.11 | 1.61 | 0.283 | 0.987 | 0.538 | 0.852 | 0.880 | 0.791 | 0.204 |
| IL-15 | 0 | 0 | 0.22 | 0 | — | — | — | — | — | — | — |
| IL-17A | 0 | 0 | 0 | 0 | — | — | — | — | — | — | — |
| Eotaxin | 0 | 0 | 0 | 0 | 0.554 | 0.792 | 0.643 | 0.512 | 0.987 | 0.976 | 0.999 |
| bFGF | 0 | 0 | 0 | 0 | 0.384 | 0.733 | 0.821 | 0.676 | — | — | — |
| G-CSF | 0 | 0 | 0 | 0 | 0.506 | 0.929 | 0.995 | 0.676 | 0.995 | 0.399 | 0.566 |
| GM-CSF | 0 | 0 | 0 | 0 | — | — | — | — | — | — | — |
| IFN-γ | 0 | 0 | 0 | 0 | 0.524 | — | — | 0.806 | — | 0.794 | 0.865 |
| IP-10 | 430.6 | 737.6 | 389.1 | 245.2 | 1.42 × 10−4** | 0.012* | 0.001** | 0.003** | 0.329 | 1.000 | 0.388 |
| MCP-1 | 121.2 | 170.2 | 131.2 | 227.5 | 0.315 | 0.574 | 0.997 | 0.573 | 0.479 | 0.989 | 0.578 |
| MIP-1α | 0 | 0 | 0 | 0 | 0.870 | 0.992 | 0.982 | 0.993 | 0.907 | 1.000 | 0.836 |
| MIP-1β | 25.6 | 32.1 | 28.0 | 29.2 | 0.805 | 0.953 | 0.987 | 0.825 | 0.983 | 0.998 | 0.841 |
| RANTES | 0 | 0 | 0 | 0 | — | — | — | — | — | — | — |
| TNFα | 0 | 0 | 0 | 0 | — | — | — | — | — | — | — |
| VEGF | 118.5 | 153.2 | 74.2 | 121.6 | 0.071 | 0.796 | 0.941 | 0.068 | 0.759 | 0.637 | 0.187 |
LogMAR VA, CRT and cytokine levels were compared among 4 groups by Kruskal-Wallis test followed by post-hoc Steel–Dwass test for each comparison. *P < 0.05, **P < 0.01.