Table 3.
Summary of our findings compared to results of other studies.
| Source | Results of our study | Other studies |
|---|---|---|
| Effect of age | Thinner INL-RPE, INL-ELM, ELM-ISOS layers with older age | Ooto et al. reported thicker central INL-ELM and ISOS-RPE, but thinner ELM-ISOS |
| Thicker central INL-ELM layer with older age | Harris et al. and Chan et al. reported no associations. | |
| Thinner central ISOS-RPE layer with older age | ||
| Effect of sex | Men had significantly thicker INL-RPE, INL-ELM, ELM-ISOS layers than women | Ooto et al. reported men had thicker OPL + ONL layers compared to women. |
| Won et al. reported men had thicker OPL and thinner ONL compared to women. | ||
| Effect of race | Black Britons had thinner INL-RPE, INL-ELM, ELM-ISOS and ISOS-RPE layers compared to Whites | NIL |
| Asians and Mixed/Others showed thinner INL-RPE and INL-ELM layers compared to Whites | ||
| Effect of smoking | Current smokers had thinner INL-RPE, ELM-ISOS and ISOS-RPE layers compared to non-smokers | Harris et al. reported smokers had thinner photoreceptor thickness in the central and inner subfields compared to non-smokers. |
| Previous smokers had thicker INL-RPE and ISO-RPE layers compared to never smokers | ||
| Effect of blood pressure | Higher blood pressure was associated with a thinner INL-RPE and ELM-ISOS | NIL |
| Effect of refractive error | Higher positive refractive error was associated with thicker INL-RPE and INL-ELM layers. | Ooto et al. reported no associations between axial length with OPL + ONL, inner or outer segments of the photoreceptors. |
| Effect of IOP | Higher IOPcc was associated with thicker INL-RPE, INL-ELM, ELM-ISOS and ISOS-RPE layers. | NIL |
Inner nuclear layer/outer plexiform layer boundary to external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE).
INL-ELM is a proxy measure of the synaptic terminals, axons and the nucleus of the photoreceptors (OPL_ONL). The ELM-ISOS and ISOS-RPE are proxy measures of the inner segment and outer segment of the photoreceptors respectively.
NIL = No other others have been reported and IOP = Intraocular pressure.