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. 2019 Dec 19;9:19429. doi: 10.1038/s41598-019-54542-y

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© The Author(s) 2019, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Principal component analysis (PCA) of the e-miRNA expression profiles in severe ICAD patients and correlation analysis between PC3 and 13 e-miRNAs. 3D Scatterplot of PCA of the e-miRNA expression profiles in severe ICAD patients (panel a). The principal component 3 (PC3) was statistically significantly associated to the outcome of response to medical management (p = 0.0052). When PC3 is used on the horizontal X axis, there is an evident differentiation in the distribution of the e-miRNA expression between ICAD patients with recurrent ischemic events despite IMM (blue dots) and those responding to medical management (red dots). Panel b shows the correlation analysis between PC3 and the modified PC3 computed by using only the 13 e-miRNAs with the highest absolute coefficients (>75% quantile). There is a preserved high correlation between the original PC3 and the modified PC3 (R² = 0.94) and the modified PC3 is able to differentiate non-responders to IMM (blue dots) from responders (red dots).