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. 2019 Dec 19;9:19450. doi: 10.1038/s41598-019-55550-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Necroptosis inhibition improves renal function and renal injury in a mouse model of Ang II-induced renal injury. (A) H&E staining of the kidney tissues retrieved from Ang II-infused mice treated with or without PD123319 or losartan or Nec-1 (n = 6 per group). Representative images are shown. (B) The tubular damage scores were assessed using a light microscope. Ang II-induced increases in blood urea nitrogen (C) and serum creatinine (D) levels were significantly reversed by PD123319 or losartan or Nec-1. (E) The systolic blood pressure was assessed. **p < 0.01 versus control; ^##p < 0.01 versus the Ang II-treated group. Ang II: angiotensin II.