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. 2019 Dec 19;10:5795. doi: 10.1038/s41467-019-13616-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a SPR depicts the binding of UCB-6786 to immobilised TNF. b The analogue, UCB-6876, specifically binds to immobilised TNF (solid black circles) but not to control proteins, capture antibody plus TNFR1 (solid black squares), capture antibody (solid black triangle pointed down) or TNFR1 (solid black triangle pointed up). c Kinetic analysis of UCB-6876 using the Biacore T100 showing slow association and dissociation rates.