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. 2019 Dec 19;10:5785. doi: 10.1038/s41467-019-13708-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Sagittal plane scheme (top) and VAF analysis (bottom) of sites of multi-regional adenomyosis (1–6) plus normal endometrium (NE), normal myometrium (NM), leiomyoma (LM), and blood (B) samples from Patient #8. VAF values are depicted as in Fig. 3. b, c Coronal plane scheme (top) and VAF analyses (bottom) of multi-regional adenomyosis plus NE and/or NM samples from the indicated patients. d–f Coronal plane scheme (top), sagittal plane scheme (middle), and VAF analyses of multi-regional adenomyosis samples plus endometriosis samples (EN) and/or NM samples from the indicated patients. For a–f, raw VAF values (%) for each sample are shown in Supplementary Data 17–19. g–i Quantification of VAF values as determined by TDS of the indicated genes in frozen (Bulk) and LCM tissues from the indicated patients. Bulk tissues included peripheral blood (B), adenomyotic lesions (A), and endometriotic lesions (EN). LCM tissues included epithelial component of adenomyosis (A), endometriosis (EN), and normal adjacent tissues (ADJ). For g–i, raw VAF values (%) for each sample are shown in Supplementary Data 21.