Skip to main content
. 2019 Dec 19;10:5785. doi: 10.1038/s41467-019-13708-y

Fig. 5. Increased mutation frequency and VAF of KRAS-mutated clones in the histologically normal endometrium adjacent to adenomyotic or endometriotic lesions.

Fig. 5

a, b Histologically normal myometrium (NM; negative control) and endometrium (NE) were macro-dissected from the indicated three groups of patients. a Occurrence of the indicated gene mutations in NE of patients with adenomyosis (patient ID column: orange), patients with neither adenomyosis nor endometriosis (patient ID column: yellow), and patients with endometriosis but without co-occurring adenomyosis (patient ID column: purple). Bottom boxes: each box represents an individual mutation of KRAS (red), PIK3CA (turquoise), or PPP2R1A (blue). VAF values are shown using individual color scales. b Quantification of VAF values as determined by TDS of the indicated mutations in the macro-dissected NM (negative control) or NE from the patients in the group A (adenomyosis; orange in a), group Non-A/E (patients with neither adenomyosis nor endometriosis; yellow in a), and group E (patients with endometriosis but without co-occurring adenomyosis; purple in a). Source data are provided as a Source Data file. Data are values for individual patients plus the mean. *p < 0.05 by Welch’s t-test.