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. 2019 Dec 19;9:19422. doi: 10.1038/s41598-019-55950-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased I_CaL and unaltered Na_v1.5 expression in MHC-Cre⁺ mouse cardiomyocytes and mouse hearts respectively. (A) Representative traces of I_CaL recorded in isolated cardiomyocytes (left panel) and quantification of I_CaL (right panel) shown a significant downregulation of the calcium current in MHC-Cre⁺ cardiomyocytes compared to the control (MHC-Cre⁻) from ≥12-week-old mice. ****p < 0.0001. (B) Cropped western blots showing Na_v1.5 expression in heart lysates from MHC-Cre⁺ and MHC-Cre⁻ ≥12-week^-old mice. The bottom panel shows the quantification of Na_v1.5 expression normalized to calnexin expression from 7 to 9 western blots. n.s. indicates a non-statistically significant difference.