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. 2019 Dec 19;9:19474. doi: 10.1038/s41598-019-55411-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental setup. (a) Chorioallantoic membrane (CAM) assay with two different biomaterials that are investigated in the same organism. (b) Empty scaffold on day 0. (c) Vascularized scaffold on day 7 as used for (m) magnetic resonance imaging (MRI). (d) Scaffold after perfusion with yellow MicroFil as used for (n) microcomputed tomography (MicroCT). (e) Scanning electron microscopy (SEM) image showing the lamellar structure of the Optimaix scaffold at 100x magnification. Scale bar = 100 μm. (f) Optimaix scaffold right after placement on the CAM and (g) after 7 days of incubation on the CAM. (h) Bottom view of the same sample after perfusion with MicroFil. (i) SEM of the DegraPol scaffold at 100x magnification shows a highly porous foam structure. Scale bar = 100 μm. (j) DegraPol scaffold right after placement on the CAM and (k) after 7 days of incubation on the CAM. (l) Bottom view of the same sample after perfusion with MicroFil. The yellow dotted lines in (f,g,j,k) indicate the outline of the scaffolds on day 0. Blue arrowheads point at capillaries at the edge between CAM and scaffold. Scale bars in (f–h,j–l) = 200 μm.