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. 2019 Dec 19;9:19474. doi: 10.1038/s41598-019-55411-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Imaging and analysis of the vasculature within Optimaix and DegraPol scaffolds. (a) Functional assessment of blood perfusion capacity by MRI. Mean ± SE, n = 4, *p < 0.05. (b) Vessel volume determined by MicroCT after MicroFil perfusion of the vasculature. Mean ± SE, n = 4. (c) Representative magnetic resonance image of Optimaix and DegraPol scaffolds on the CAM before and after injecting paramagnetic Gadolinium-DOTA contrast agent. (d) Representative maximum intensity projections of MicroCT scans and of binarized images for both Optimaix and DegraPol scaffolds. (e) Correlation of total blood perfusion capacity (MRI) and total vessel volume (MicroCT) for Optimaix scaffolds. (f) Correlation of total blood perfusion capacity (MRI) and total vessel volume (MicroCT) for DegraPol scaffolds. Scale bars = 250 μm.