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. 2019 Dec 19;10:5791. doi: 10.1038/s41467-019-13433-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The genome position of each locus is plotted against its −log₁₀(P value). Depicted, from the inner to the outermost ring, are the recovered (DL) single site, acute (DC) single site, and DC cluster-based differential methylation results. Red lines mark the Bonferroni threshold of significance for each analysis. Black (N = 157) and red dots (N = 166) pass this significance threshold, in their respective analyses. Gene symbols around the plot perimeter represent the gene(s) within 10 kb of the significantly differentially methylated clusters (outer ring). Gene symbols in blue are hypomethylated in ESAM, gene symbols in orange are hypermethylated. b Volcano plot of effect sizes among all DC single sites. c Concordance of effect size and adjusted statistical significance between Jamaica and Malawi DC samples at the N = 157 Bonferroni-significant single CpG sites; ten sites were found to be age-sensitive in each of the country-specific analyses and were omitted (Methods). All P values are based on t test results from regression analyses.