Fig. 5.

Biological pathways that are enriched in (a) CRISPR-sensitive housekeeping genes and (b) shRNA-sensitive housekeeping genes. CRISPR-sensitive housekeeping genes are defined as those that showed significantly stronger gene essentiality in CRISPR screens versus shRNA screens, whereas shRNA-sensitive housekeeping genes are defined oppositely. LogFDR is the log10 of probability that a gene set with a given enrichment score represents a false positive, determined using the GSEA method [41]. A higher –logFDR, i.e. a lower FDR indicates less false positive rate.