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. 2019 Nov 12;50:67–80. doi: 10.1016/j.ebiom.2019.10.051

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© 2019 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 6 — The predicted CES essentiality in genomic amplified regions. (a–c) Increased essentiality driven by a higher copy number in oncogenes KRAS, MYC, and CCND1, captured by CES but not by CRISPR or shRNA scores. (d) Difference of CES for cancer essential genes and their neighbouring genes does not correlate with their genomic distances. (e) CCND1 was predicted as a top essential gene by CES from the amplified 11q13 genomic region in cell line A673. (f,g) CES separates housekeeping genes (f) and common essential genes (g) from non-essential genes under the same scenario of copy number quantiles.