Table 2.

Subgroup analysis of acetoacetate (per 10 µmoL/L increase) for all-cause death.

Factor	Subgroup	N	HR	95%CI	P value	InteractionP value
Total		615	1.020	1.010–1.030	<0.001
Age	Age 67 years <	245	0.932	0.784–1.104	0.402	0.284
	Age 67 years ≥	370	1.020	1.010–1.020	<0.001
Sex	Male	374	1.010	1.001–1.020	0.004	0.005
	Female	241	1.051	1.030–1.083	<0.001
NYHA classification	I, II	362	1.041	1.041–1.051	<0.001	0.001
	III, IV	253	1.010	0.990–1.020	0.335
Ischemic etiology	±	147	1.010	1.001–1.020	0.047	0.110
	–	468	1.030	1.010–1.040	<0.001
Hypertension	±	395	1.010	1.001–1.030	0.011	0.094
	–	220	1.030	1.010–1.041	<0.001
Diabetes mellitus	±	256	1.010	1.000–1.020	0.057	0.013
	–	359	1.041	1.020–1.051	<0.001
Dyslipidemia	±	392	1.020	1.010–1.030	<0.001	0.668
	–	223	1.010	0.990–1.041	0.305
Atrial fibrillation	±	249	1.030	1.010–1.051	0.015	0.479
	–	336	1.020	1.010–1.030	<0.001
Chronic kidney disease	±	324	1.030	1.020–1.051	<0.001	0.060
	–	291	1.010	1.000–1.030	0.026
Anemia	±	293	1.010	1.010–1.020	<0.001	0.590
	–	322	1.020	1.000–1.051	0.094
Log BNP	Mean 2.3 ≥	340	1.010	1.001–1.020	0.042	0.007
	Mean 2.3 <	275	1.030	1.020–1.041	<0.001

HR, hazard ratio; CI, confidence interval; NYHA, New York Heart Association; BNP, B-type natriuretic peptide.