Comparison 1. Racecadotril versus placebo/no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure of rehydration	2	192	Risk Ratio (M‐H, Fixed, 95% CI)	0.41 [0.13, 1.23]
2 Number of stools within 24 hours	2	258	Mean Difference (IV, Fixed, 95% CI)	‐0.24 [‐0.90, 0.43]
3 Number of stools between 24 to 48 hours	2	258	Mean Difference (IV, Random, 95% CI)	‐0.80 [‐1.87, 0.27]
4 Stool output within 24h	1	167	Mean Difference (IV, Fixed, 95% CI)	‐5.5 [‐7.71, ‐3.29]
5 Stool output within 48h	2		Std. Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.1 Stool output within 48 hours (all patients)	2	301	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.65 [‐0.88, ‐0.41]
5.2 Stool output within 48 hours (rotavirus‐positive patients)	2	128	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.83 [‐1.19, ‐0.47]
6 Adverse events	5	688	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.66, 1.22]