Study	Reason for exclusion
Calatayud 2009	Observational study
Chacón 2010	Observational study
Cojocaru 2002	Not an RCT
Melendez‐Garcia 2007	The control agent is kaolin/pectin
Michael 2014	Observational study
NCT03463512	Children aged from 3 months to 17 years
Rautenberg 2012	Cost effectiveness study, not an RCT
Tiholova 2010	Only abstract available; observational study
Torrez 2013	Only abstract available. 52% failed to complete the treatment
Turck 1999	Racecadotril was compared with loperamide

Abbreviations: RCT: randomized controlled trial.