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. 2019 Dec 18;9(4):2045894019878599. doi: 10.1177/2045894019895452

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 1. — Cardiac changes after 20 weeks of high fat diet. (a) H&E stain of cross-section of hearts from AKR and C3H mice fed high fat diet confirms that AKR, but not C3H, mice develop biventricular cardiac hypertrophy. (b) M-mode and transmitral Doppler echocardiography confirms ventricular hypertrophy and E to A reversal in AKR mice. (c) Representative pressure volume loops from AKR mice show biventricular concentric and eccentric remodeling consistent with HFpEF. (d) Preserved ejection fraction by echo in AKR and C3H mice. (e and f) AKR mice fed high fat diet selectively demonstrate elevated right and left ventricular end-diastolic pressures. *p < 0.05, **p < 0.01, and ***p < 0.001 compared to other groups. Data presented as mean ± standard deviation.

HFD: high fat diet. LVEF: left ventricular ejection fraction; LVEDP: left ventricular end-diastolic pressure; RVEDP: right ventricular end-diastolic pressure.