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. 2019 Sep 11;28(12):1614–1623. doi: 10.1177/0963689719875409

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig 1. — Circular matrix metalloproteinase 9 (circ-MMP9) is upregulated in oral squamous cell carcinoma (OSCC) and positively correlated with MMP9 expression. (a) Quantitative real-time PCR (qRT-PCR) analysis for the expression of the indicated three circRNAs in OSCC and matched normal tissues. (b) qRT-PCR analysis for circ-MMP9 expression in OSCC cell lines. (c) The survival curve of OSCC patients based on the median circ-MMP9 expression value. (d) qRT-PCR analysis for circ-MMP9 expression in plasma samples. (e) Receiver operating characteristic curve of OSCC patients based on plasma circ-MMP9 expression. (f) qRT-PCR analysis for circ-MMP9 and MMP9 expression in circ-MMP9-depleted UM1 and HSC-3 cells. (g) Western blot analysis for MMP9 protein expression circ-MMP9-depleted UM1 and HSC-3 cells. (h) qRT-PCR analysis for MMP9 expression in 74 pairs of OSCC and normal tissues. (i) The correlation between circ-MMP9 and MMP9 expression in OSCC tissues. *p < 0.05, **p < 0.01, ***p < 0.001.