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. 2019 Sep 17;28(12):1674–1685. doi: 10.1177/0963689719874048

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — EPC transplantation decreased the ventilation-induced increase of MMP-9, phosphorylated NF-κB and phosphorylated MLC in the rat VILI model. The representative results of the expression of MMP-9 (upper panel of A and B), total-NF-κB (secondary panel of A and C), phosphorylated NF-κB (third panel of A and D), and phosphorylated MLC (forth panel of A and E) in lung tissues in the S group (left bands of A and of B–E), V group (middle bands of A and of B–E) and VE group (right bands of A and of B–E) were detected by Western blot. The corresponding protein expression was evaluated by densitometry and presented in B (MMP-9), C (total-NF-κB), D (phosphorylated NF-κB), and E (phosphorylated MCL). Data from each group were calculated from three independent experiments. *p < 0.05, when compared with the S group; ^# p < 0.05, when compared with the V group. Abbreviations: EPCs, endothelial progenitor cells; MLC, myosin light chain; MMP, matrix metalloprotease; NF-κB, nuclear factor kappa B; S group, sham; V group, VILI; VE group, VILI with EPC transplantation; VILI, ventilator-induced lung injury.

Inline graphic — EPC transplantation decreased the ventilation-induced increase of MMP-9, phosphorylated NF-κB and phosphorylated MLC in the rat VILI model. The representative results of the expression of MMP-9 (upper panel of A and B), total-NF-κB (secondary panel of A and C), phosphorylated NF-κB (third panel of A and D), and phosphorylated MLC (forth panel of A and E) in lung tissues in the S group (left bands of A and of B–E), V group (middle bands of A and of B–E) and VE group (right bands of A and of B–E) were detected by Western blot. The corresponding protein expression was evaluated by densitometry and presented in B (MMP-9), C (total-NF-κB), D (phosphorylated NF-κB), and E (phosphorylated MCL). Data from each group were calculated from three independent experiments. *p < 0.05, when compared with the S group; ^# p < 0.05, when compared with the V group. Abbreviations: EPCs, endothelial progenitor cells; MLC, myosin light chain; MMP, matrix metalloprotease; NF-κB, nuclear factor kappa B; S group, sham; V group, VILI; VE group, VILI with EPC transplantation; VILI, ventilator-induced lung injury.