Table 3.

Histological factors/classification/grading associated with worse OS/DSS in panNENs

Factors	Metastatic/Advanced		All stage
	OS	DSS	OS	DSS
Histological factor/Classification/Grading
Grade	[12, 14–16, 36, 80, 93, 101, 115]	[16]	[23–27, 30, 31, 39, 94, 104, 116–121]	[26]
Grade	[17, 113, 331]		[22, 29, 38, 56, 57, 147, 319]	[33, 62, 288]
Ki-67 index	[17, 54, 91, 102, 111]/[111]		[59, 103, 123, 137, 140]/[29, 38, 56, 57, 122, 321]
Higher Ki-67 in metastatic lesions	[113]
Mitosis			[38]/[29]
Differentiation, moderate	[5]		[28, 35, 51]/[20, 29]	[28, 51]
Differentiation, poorly	[5, 11, 13]/[124, 133]	[11, 13]	[20, 21, 28, 32, 35, 51, 122, 123]/[29, 129, 130, 132]	[28, 34, 35, 51, 98]
Stage(AJCC, ENETS)			[22–24, 26–28, 30, 116–119, 121–123, 136–138]	[26, 28, 33]
Stage(AJCC, ENETS)			[29, 38, 56, 59, 119, 120, 139, 319]
Size	[19]/[93]		[20, 26, 28, 139]/[29, 97, 120, 327]	[28]/[26]
T stage			[35]/[20, 94]	[34]
Adjacent invasion			[21]/[29, 38]
Lymphovascular invasion			[29]
Perineural invasion			[29]
Lymph nodes metastasis	[37]/[11, 15, 113]	[37]/[11]	[20, 21, 25, 97]/[94, 122, 136, 147, 319]	[34, 62]
Distant metastasis	[93, 111]		[19–21, 25, 26, 28, 35, 51, 104, 140, 141]/[29, 38, 57, 94, 120, 122, 147]	[28, 33–35, 51]/[26, 62, 288]
Hepatic tumor burden	[17, 54, 102, 113]		[140]
Number of metastatic sites			[39]/[104, 122]
Thymic tumor			[19]
Anatomical location, head/neck	[15, 100, 101]	[100]	[23, 27, 30, 32, 35, 51]/[20, 26, 28, 319]	[35, 51]/[26]

See Table 1. legend for explanation of data included.

AJCC, American Joint Committee on Cancer; DSS, disease-specific survival; ENETS, European Neuroendocrine Tumor Society; OS, overall survival.