Table 7.
Pathological factors associated with worse DFS(recurrence) and OS/DSS after surgical resection in panNENs
| Factors | DFS | OS | DSS |
|---|---|---|---|
| Molecular factor | |||
| ALT, positive | [102, 150] | [149] | |
| CD133, positive | [253] | ||
| Cytokeratin19, high | [261] | ||
| CNPY2, positive | [286] | ||
| DAXX/ATRX , loss | [102, 149–151] | [148] | [149] |
| DAXX, loss + STC2, high | [299] | ||
| Endocan, high | [294] | ||
| Gastrin, positive | [184] | ||
| H3K36me3/ARID1A/CDKN2A, loss/deletion | [149] | [149] | |
| HOPX , low | [336] | ||
| HOPX, hypermethylation | [336] | ||
| FoxP3+ tumor-infiltrating Lymphocyte, high | [187] | ||
| HDAC score, high | [290] | ||
| HuD(RNA binding protein), negative | [189] | ||
| IPM3, positive | [265] | ||
| MCM7 , high | [250] | ||
| miRNA-21, positive | [304] | [304] | |
| miRNA-449a, positive(with/without HDAC4) | [293] | [293] | |
| miRNA-196a , positive | [259] | ||
| PAX6, low | [337] | ||
| PHH3, positive | [230, 296] | [230, 296] | |
| PR, loss and/or PTEN , low | [136] | [136] | |
| SSTR2A, positive | [338] | ||
| STK33, positive | [192] | ||
| TPD52, low | [247] | [247] | |
| Tumor associated macrophage, high | [251] | [251] | |
| UCHL1/α-internexin, negative | [254] | ||
| 16257 C/A SNP | [297] |
See Table 3. legend for explanation of data included.
ALT , alternative lengthening of telomeres; ARID1A, AT-rich interactive domain 1A; ATRX, alpha-thalassemia/mental retardation syndrome X-linked; CDKN2A, cyclin-dependent kinase Inhibitor 2A; CNPY2 canopy FGF signaling regulator 2; DAXX, death domain-associated protein; DFS, disease-free survival; DSS, disease-specific survival; FoxP3, forkhead box P3; H3K36me3, histone H3 trimethylation at lysine 36; HDAC, histone deacetylase; HOPX, homeobox only protein homeobox; IPM3, insulin-like growth factor-II mRNA-binding protein 3; MCM7, minichromosome maintenance complex component 7; miRNA, microRNA; OS, overall survival; PAX6, paired box 6; PHH3, phosphohistone H3; PR, progesterone receptor; PTEN, phosphatase and tensin homolog deleted from chromosome 10; SNP, single nucleotide polymorphism; SSTR, somatostatin receptor; STC2, stanniocalcin-2; STK33, serine/threonine kinase 33; TPD52, tumor protein D52; UCHL1, ubiquitin carboxy-terminal hydrolase L1.