Table 6.

DCIS mRNA staining: Significant risk associations with subsequent tumor events

	HR† (95% CI)	P-value‡
Years to any event: DCIS or invasive
TGFB1	8.26 (3.22–21.16)	0.0001
Years to first invasive event
TGFB1	7.85 (1.92–32.11)	<0.0001
Years to first ipsilateral event
Non-Proliferation§ Gp.	3.06 (1.48 – 6.35)	0.003
TGFB1	7.85 (1.92–32.11)	0.004
Years to first DCIS event
Non-Proliferation§ Gp.	2.13 (1.01 – 4.47)	0.047
Prolif.¶ or Non-Prolif.§ Gp. with > 10% staining: associations with outcome
Any recurrence	1.98 (1.08–3.64)	0.027
DCIS	2.30 (1.13–4.50)	0.022
Ipsilateral	3.19 (1.62–1.43)	0.001

^†Hazard ratio (HR) per unit increase in ordinal staining scale.

^‡P-value test for trend.

^§(BIRC5, Cyclin B1, MKI67, MYBL2, STK15);

^¶(CEACAM5, HTF9C, NDRG1, SLC7A5, TP53).

Note: DCIS patients with recurrences n=55. Complete data analyses tables are provide in Supporting Information Tables 1 and 2.