Table 2.

Self-reported race- and ethnicity-stratified comparisons of epigenetic aging Z-scores and the prevalence of HANA conditions between IL-10 genotype groups.

	IL-10 C/C Homozygotes	IL-10 C/A or A/A genotypes	F statistic from ANCOVA, p-value
Self-reported Whites
n (subset with HANA condition data)	61 (35)	42 (31)	-
Epigenetic aging Z-score, M (SD)	0.14 (0.83)	0.00 (0.86)	F(1,99)=0.93, p=.34 (Cohen’s d=0.16)
% Past/current HANA condition	48.6	58.1	OR=0.44, (95%CI=0.13–1.48), p=.19
Self-reported Blacks
n (subset with HANA condition data)	15 (10)	27 (19)	-
Epigenetic aging Z-score, M (SD)	0.21 (1.02)	−0.22 (1.06)	F(1,38)=3.45, p=.07 (Cohen’s d=0.41)
Self-reported non-Hispanics
n (subset with HANA condition data)	66 (39)	53 (39)	-
Epigenetic aging Z-score, M (SD)	0.13 (0.85)	−0.12 (1.01)	F(1,115)=2.46, p=.12 (Cohen’s d=0.27)
% Past/current HANA condition	53.8	59.0	OR=0.74, (95%CI=0.26–2.07), p=.56
Self-reported Hispanics
n (subset with HANA condition data)	13 (9)	23 (17)	-
Epigenetic aging Z-score, M (SD)	0.31 (0.96)	−0.28 (0.90)	F(1,32)=4.73, p=.04 (Cohen’s d=0.63)

Note. The size of IL-10 genotype groups among self-reported Blacks and Hispanics with HANA data lacked sufficient statistical power to examine differences in prevalence rates of past/current HANA conditions according to Paduzzi, 1996. Cohen’s d is an effect size used to indicate the standardized difference between two means: 0.2=small, 0.5=medium, 0.8=large. ANCOVA = analysis of covariance. M = mean, SD = standard deviation, OR = odds ratio, CI = confidence interval.