Table 3.

The diagnostic accuracy of optimal cut-offs^† for non-invasive markers in identifying advanced fibrosis in adults with HBV-HIV coinfection.

Biomarker	AUROC	SE, %	SP, %	SE + SP	PLR	NLR	PPV, %	NPV, %	AC, %
APRI ≥ 0.42 (n=106)	0.678	62.5	73.2	135.7	2.3	0.51	40.5	87.0	70.8
FIB-4 ≥ 1.76 (n=106)	0.634	50.0	76.8	126.8	2.2	0.65	38.7	84.0	35.8
VCTE ≥ 7.8 kPa (n=63)	0.778	61.5	94.0	155.5	10.3	0.41	72.7	90.4	87.3
Established > 7.6 kPa	0.768	61.5	92.0	153.5	7.69	0.42	66.7	90.2	85.7

Abbreviations: AC, accuracy; APRI, aspartate aminotransferase to platelet ratio index; AUROC, area under the receiver operating characteristic curve; FIB-4, fibrosis index based on four factors (i.e., age, platelet count, aspartate aminotransferase and alanine aminotransferase); VCTE, vibration controlled transient elastography; kPa, kiloPascals; NLR, negative likelihood ratio, NPV, negative predictive value; PLR, positive likelihood ratio; PPV positive predictive value; SE, sensitivity; SP, specificity.

^†The cut-off with the highest SE+SP; the higher number, the higher the diagnostic accuracy.