Table 4.

The diagnostic accuracy of non-invasive markers to exclude^† and confirm^‡ advanced fibrosis in adults with HBV-HIV coinfection.

Biomarker	AUROC	SE, %	SP, %	PLR	NLR	PPV, %	NPV, %
APRI (n=106)
Exclusionary cut-off ≤ 0.22	0.565	95.8	17.1	1.2	0.24	25.3	93.3
Confirmatory cut-off ≥ 1.00	0.619	25.0	98.8	20.5	0.76	85.7	81.8
FIB-4 (n=106)
Exclusionary cut-off ≤ 0.88	0.571	95.8	18.3	1.2	0.23	25.6	93.8
Confirmatory cut-off ≥ 3.01	0.577	16.7	98.8	13.7	0.84	80.0	80.2
VCTE, kPa (n=63)
Exclusionary cut-off ≤ 5.0	0.772	92.3	62.0	2.43	0.12	38.7	96.9
Confirmatory cut-off ≥ 8.8	0.749	53.8	96.0	13.5	0.48	77.8	88.9

Abbreviations: AC, accuracy; APRI, aspartate aminotransferase to platelet ratio index; AUROC, area under the receiver operating characteristic curve; FIB-4, fibrosis index based on four factors (i.e., age, platelet count, aspartate aminotransferase and alanine aminotransferase); VCTE, vibration controlled transient elastography; kPa, kiloPascals; NLR, negative likelihood ratio, NPV, negative predictive value; PLR, positive likelihood ratio; PPV positive predictive value; SE, sensitivity; SP, specificity.

^†Criteria for the exclusionary cut-off were sensitivity >90% and negative likelihood ratios (NLR) ≤0.1; if no cut-off met these criteria, among cut-offs with >90% sensitivity, the cutoff with the lowest NLR was selected.

^‡Criteria for the confirmatory cut-off were specificity >90% and positive likelihood ratio (PLR) ≥10; if more than one cut-off met these criteria, the cut-off with the highest specificity was selected; if no cut-off met these criteria, among cut-offs with >90% specificity, the cut-off with the highest PLR was selected.